MOTS-C (10MG & 40MG)

MOTS-c Research Peptide

MOTS-c is a mitochondrial derived research peptide made of 16 amino acids and encoded by mitochondrial DNA. Researchers study this peptide in controlled laboratory settings to better understand mitochondrial signaling and cellular energy related activity. Its defined sequence helps laboratories design repeatable studies under clear and stable research conditions.

Because MOTS-c comes from mitochondrial DNA, researchers use it to study how mitochondria communicate with the nucleus during stress based test models. This peptide shows unique behavior among mitochondrial peptides because it can move into the nucleus under certain test conditions. As a result, research teams can examine how signals from mitochondria affect gene activity inside the cell nucleus.

In laboratory studies, scientists use MOTS-c to explore pathways linked to mitochondrial growth, antioxidant response systems, and cellular adaptation. This focused research approach allows laboratories to study how mitochondrial signals guide cellular responses while keeping strong control over test conditions.

Researchers value MOTS-c for its clear origin, defined structure, and fit within structured research workflows. Its consistent makeup helps reduce variation during testing and supports comparison across studies that involve mitochondrial peptides. In addition, its predictable handling makes it suitable for long term laboratory research projects.

Ongoing research continues to include MOTS-c in peptide based laboratory studies. Its mitochondrial origin, clear sequence, and signaling role make it a useful tool for advanced experimental work focused on mitochondrial and nuclear interaction models.

Important Notice

MOTS-c is provided strictly for research use only. Researchers must not use this product for human or animal use, clinical purposes, diagnostic work, or consumption. Qualified professionals must conduct all research in proper laboratory settings and in line with applicable rules and guidelines.

No research information available for this product.

Lot Number: MOT1011242025-12 Purity: 99.7% Date: January 22, 2026 View COA Archive

Peptide Research Overview

Peptides are short chains of amino acids studied for their role in cellular signaling and molecular interactions. In research settings, they are commonly used to explore biological pathways and structure–function relationships.

Across scientific disciplines, peptide research supports advances in biochemistry and molecular biology. Their precision and adaptability make peptides essential tools in modern laboratory research.

Key Benefits of Peptides in Research

• Support precise investigation of cellular signaling pathways

• Enable targeted structure–function research at the molecular level

• Offer high specificity for controlled experimental design

• Adapt easily across a wide range of research applications

• Aid in studying protein interactions and biological responses

• Allow consistent and repeatable laboratory testing

• Integrate well with modern analytical and research methods

• Serve as foundational tools in biochemical and molecular research

Advancing Scientific Research with Peptides

Peptides continue to serve as essential components in modern research due to their flexibility, precision, and well-defined structures. In laboratory settings, researchers rely on peptides to examine biological mechanisms, evaluate molecular interactions, and refine experimental models with a high level of control. Their scalable nature and compatibility with advanced analytical techniques make peptides valuable across both foundational studies and ongoing research development, supporting consistent, reproducible outcomes in controlled scientific environments.

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a mitochondrial-derived peptide (MDP) encoded in the short open reading frame within mitochondrial DNA. It consists of 16 amino acids and is expressed in multiple tissues.

MOTS-c was first identified in 2015 as part of a class of signaling peptides encoded by mitochondrial DNA rather than nuclear DNA, expanding understanding of mitochondrial communication with the cell nucleus.

MOTS-c engages in mitochondrial-to-nuclear signaling by translocating to the nucleus under metabolic stress and modulating gene expression via pathways such as folate-AICAR-AMPK, which are key regulators of energy metabolism and cellular stress responses.

MOTS-c has been studied in controlled models to explore its role in metabolic regulation, including glucose uptake, insulin sensitivity, and lipid metabolism via muscle signaling pathways and mitochondrial energy regulation.

In experimental studies, MOTS-c expression increases with metabolic stress and exercise, and it has been linked to mitochondrial-mediated regulation of skeletal muscle energy use, adaptive metabolic signaling, and response to aging-related changes in metabolism.

Researchers are interested in MOTS-c because it represents a mitochondrial signal molecule that integrates energy metabolism, stress signaling, and gene regulation. Its discovery has advanced understanding of how mitochondria communicate with the nucleus to influence cellular homeostasis.

Research Use Only – Legal Disclaimer

All Simple Peptide products labeled as Research Use Only (RUO) are intended strictly for laboratory, investigational, and scientific research purposes. These materials are not approved by the FDA and are not intended for human or veterinary use, clinical applications, diagnostic procedures, or therapeutic treatment of any kind.

By purchasing or using RUO materials, you acknowledge that they will be handled only within an appropriate research environment by qualified personnel who understand the risks, limitations, and regulatory requirements associated with experimental compounds. Products must not be administered to humans or animals, offered as therapeutic agents, or represented as safe or effective for any medical purpose.

Use of these materials is entirely at your own risk. Simple Peptide assumes no liability for misuse, unsafe handling, improper application, or any regulatory or compliance issues arising from their use.

Frequently bought together: MOTS-C/GHK-CU/KPV Blend, NAD+ (500MG & 1000MG), NAD+ (BUFFERED)